The goal of research ethics is to protect human subjects from harm when they participate in a study. In the digital age, however, what constitutes “participation” has become blurry, especially with the rise of social media platforms and other online apps and services. Furthermore, new applications of big data raise important questions about how to protect consumers from harms, and what kinds of notice and consent should be obtained. This course provides an introduction and overview of research ethics in the 21st century and evaluates the many challenges to conducting ethical research.